In 1996 a team of Swedish scientists discovered why HGH replacement makes people feel good. The scientists found it acts on the brain just like an antidepressant, raising the level of the neurotransmitter B-endorphin, which has been called the brain's opiate. HGH also lowers the level of dopamine, which is associated with feelings of agitation.

Other reports indicate that increased levels of HGH reduce stress, improve focus and concentration, and build self-esteem and self-confidence. A 1998 report showed that depressed men have a marked decrease in HGH secretion during the first three hours of sleep as opposed to nondepressed controls. Indeed, higher levels of HGH induced more restful and sounder sleep.

Three different studies in Sweden, Denmark, and England reported that HGH replacement therapy had dramatic, positive effects on patients suffering from low self-esteem, anxiety, and depression.

In a report by L. Cass Terry, M.D., Ph.D., to the American Academy of Anti-Aging Medicine in December 1996, Dr. Terry reported that his clinical group of 900 people, 300 or which were doctors, 80% experienced improved attitude toward life, and 67% experienced enhanced emotional stability.
A recent clinical study by Theirry Hertoghe, M. D. showed that HGH therapy decreased depression by 82% and anxiety and low self-esteem by over 70%

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